IRS1/4 IGF1/2:p-IGF1R IGF1/2:p-IGF1R:IRS1/4 IGF1/2:p-IGF1R binds IRS1/4 Authored: May, B, 2012-08-06 Edited: May, B, 2012-08-06 IRS1 binds the NPEY-juxtamembrane motif of phosphorylated IGF1R (Craparo et al. 1995, He et al. 1995, Huang et al. 2001). IRS4 is also involved in signaling by IGF1R and is presumed to bind phosphorylated IGF1R in the same way as IRS1 (Qu et al. 1999, Cuevas et al. 2007). IRS1 and IRS4 are located at the plasma membrane (Karlsson et al. 2004, Fantin et al. 1998). Pubmed10531310 Pubmed11557037 Pubmed15182363 Pubmed17408801 Pubmed7541045 Pubmed7559478 Pubmed9553137 Reactome Database ID Release 432428930 Reactome, http://www.reactome.org ReactomeREACT_150315 Reviewed: Holzenberger, Martin, 2012-11-09