Viral dsRNA:TLR3 recruits TRIF TRAM:TLR4:MD2:LPS:CD14 recruits TRIF Negative regulator SARM binds to TRIF PathwayStep6729 PathwayStep6704 PathwayStep6705 PathwayStep6706 MyD88-independent cascade Authored: de Bono, B, 2005-08-16 10:54:15 Edited: Shamovsky, V, 2012-11-06 GENE ONTOLOGYGO:0002756 MyD88-independent signaling route utilizes TRAM and TRIF adapters, that are essential for production of both type 1 interferons(IFNs) and pro-inflammatory cytokines. TRAM is thought to bridge between activated TLR4 and TRIF. Pubmed12855817 Pubmed14556004 Pubmed15276183 Pubmed18222170 Pubmed18297073 Reactome Database ID Release 43166166 Reactome, http://www.reactome.org ReactomeREACT_6809 Reviewed: Fitzgerald, Katherine A, 2012-11-13 Reviewed: Gay, NJ, 2006-04-24 16:48:17 Reviewed: Gillespie, ME, 2010-11-30 TRIF-mediated TLR3/TLR4 signaling