PathwayStep6722 PathwayStep6728 PathwayStep6714 PathwayStep6718 MAP kinase activation in TLR cascade TAK1 activates NFkB by phosphorylation and activation of IKKs complex IKK complex recruitment mediated by RIP1 TRAF6 mediated induction of TAK1 complex TRIF-mediated programmed cell death TRIF-mediated TLR3/TLR4 signaling Authored: Shamovsky, V, 2010-06-01 Edited: Shamovsky, V, 2010-11-15 GENE ONTOLOGYGO:0035666 Pubmed12855817 Pubmed14739303 Pubmed15814722 Reactome Database ID Release 43937061 Reactome, http://www.reactome.org ReactomeREACT_25281 Reviewed: Fitzgerald, Katherine A, 2012-11-13 Reviewed: Gillespie, ME, 2010-11-30 TRIF was shown to induce IRF3/7 and NF-?B activation and apoptosis through distinct intracellular signaling pathways [Han KJ et al 2004; Kaiser WJ and Offermann MK et al 2005]. TRIF consists of an N-terminal region (1-234), a TIR domain (235-500), and a C-terminal region (501-680).<p> The N-terminal region of TRIF harbors TRAF (TNF receptor associated factor) family proteins and forms complexes containing IRF-3 and/or NFkB -activating kinases. The C-terminal region of TRIF can recruit receptor-interacting protein-1 (RIP-1), and this event is followed by the activation of IKK complex. Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon PathwayStep3439 PathwayStep3485