PathwayStep6769 PathwayStep6798 PathwayStep6733 PathwayStep6731 PathwayStep6764 PathwayStep6805 PathwayStep6676 PathwayStep6702 Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor 5 (TLR5) Cascade Toll Like Receptor 9 (TLR9) Cascade Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 2 (TLR2) Cascade Toll Like Receptor 3 (TLR3) Cascade Toll Receptor Cascades Authored: de Bono, B, Gillespie, ME, Luo, F, Gay, NJ, 0000-00-00 00:00:00 In human, ten members of the Toll-like receptor (TLR) family (TLR1-TLR10) have been identified (TLR11 has been found in mouse, but not in human). All TLRs have a similar Toll/IL-1 receptor (TIR) domain in their cytoplasmic region and an Ig-like domain in the extracellular region, where each is enriched with a varying number of leucine-rich repeats (LRRs). Each TLR can recognize specific microbial pathogen components. The binding pathogens component of the TLRs initializes signaling pathways that lead to induction of Interferon alpha/beta. There are three main signaling pathways: the first is a MyD88-dependent pathway that is common to all TLRs, except TLR3; the second is a TRAM-dependent pathway that is peculiar to TLR3 and TLR4 and is mediated by TRIF and RIP1; and the third is a TRAF6-mediated pathway peculiar to TLR3 (Takeda & Akira 2004; Akira 2003; Takeda & Akira 2005; Kawai 2005; Heine & Ulmer 2005). Pubmed12893815 Pubmed14751757 Pubmed15585605 Pubmed15950447 Pubmed15976490 Reactome Database ID Release 43168898 Reactome, http://www.reactome.org ReactomeREACT_6966 Reviewed: D'Eustachio, P, Gale M, Jr, Gay, NJ, 2006-10-31 16:43:59 Toll Like Receptor 10 (TLR10) Cascade Trafficking and processing of endosomal TLR