PathwayStep6677 PathwayStep6701 Ligand binds to TLR10 MyD88 cascade initiated on plasma membrane Toll Like Receptor 10 (TLR10) Cascade Authored: Luo, F, 2005-11-10 11:23:18 Edited: Shamovsky, V, 2011-08-12 Little is known about TLR10 ligands. It has been established that the receptor homodimerizes upon binding and signals in an MyD88-dependent manner (Hasan U et al 2005; Nyman T et al 2008). It may also heterodimerize with TLRs 1 and 2. It is expressed in a restricted fashion as a highly N-glycosylated protein detectable in B cells and dendritic cells. Pubmed15728506 Pubmed18332149 Reactome Database ID Release 43168142 Reactome, http://www.reactome.org ReactomeREACT_9027 Reviewed: Gale M, Jr, 2006-10-31 16:45:01 Reviewed: Gillespie, ME, 2011-02-10