Collagen type VI dimer Collagen type VI Dimerization of procollagen type VI Authored: Jupe, S, 2010-07-20 Collagen type VI forms dimers and tetramers before secretion (Furthmayr et al. 1983, von der Mark et al. 1984, Engel et al. 1985, Colombatti et al. 1987). The monomers associate in antiparallel with a 30nm axial shift, intertwining 4 or 5 times (Furthmayr et al. 1983). These associate laterally to form tetramers (Furthmayr et al. 1983, von der Mark et al. 1984)The tetramers associate to form microfibrils in a non-covalent manner, presumed to be mediated through A domain interactions (Baldock et al. 2003). Collagen type VI chains are extensively post translationally modifed by the hydroxylation of proline and lysine residues (Myllyharju & Kivirikko 2004) and subsequent glycosylation of hydroxylysine, thought to be essential for tetramer formation and secretion (Sipila et al. 2007). Edited: Jupe, S, 2012-05-14 Pubmed12473679 Pubmed12823969 Pubmed14698617 Pubmed17873278 Pubmed3117786 Pubmed3938630 Pubmed6307276 Pubmed6432530 Reactome Database ID Release 431614460 Reactome, http://www.reactome.org ReactomeREACT_121253 Reviewed: Canty-Laird, EG, 2012-05-24 has a Stoichiometric coefficient of 2