PathwayStep6558 PathwayStep6559 Activation of RasGRP1 and RasGRP3 by Recruitment to the Membrane and Phosphorylation Activation of RAS by RasGRP1 and RasGRP3 Activation of RAS in B Cells Authored: May, B, 2011-01-03 Edited: May, B, 2011-01-03 Pubmed10777492 Pubmed10835426 Pubmed10934204 Pubmed11221888 Pubmed12730099 Pubmed15657177 Pubmed17283063 RasGRP1 and RasGRP3 bind diacylglycerol at the plasma membrane (Lorenzo et al. 2001) and are phosphorylated by protein kinase C (Teixeira et al. 2003, Zheng et al. 2005). Phosphorylated RasGRP1 (Roose et al. 2007) and RasGRP3 (Ohba et al. 2000, Yamashita et al. 2000, Rebhun et al. 2000, Lorenzo et al. 2001) then catalyze the exchange of GDP for GTP bound by RAS, thereby activating RAS. Reactome Database ID Release 431169092 Reactome, http://www.reactome.org ReactomeREACT_118778 Reviewed: Wienands, J, 2012-02-11