PathwayStep6560 PathwayStep6557 PIP3 activates AKT signaling Activation of RAS in B Cells Downstream Signaling Events Of B Cell Receptor (BCR) Authored: May, B, 2010-12-09 Edited: May, B, 2010-12-09 Pubmed17052215 Pubmed19909372 Reactome Database ID Release 431168372 Reactome, http://www.reactome.org ReactomeREACT_118638 Reviewed: Wienands, J, 2012-02-11 Second messengers (calcium, diacylglycerol, inositol 1,4,5-trisphosphate, and phosphatidyinositol 3,4,5-trisphosphate) trigger signaling pathways: NF-kappaB is activated via protein kinase C beta, RAS via RasGRP proteins, NF-AT via calcineurin, and AKT via PDK1 (reviewed in Shinohara and Kurosaki 2009, Stone 2006). Activation of NF-kappaB in B Cells PathwayStep3897