ub-p-PER1/2 ubiquitin Beta-TrCP1:PER Ubiquitination of PER Proteins Authored: May, B, 2009-05-17 22:04:50 EC Number: 6.3.2.19 Edited: May, B, 2009-06-02 00:51:49 Edited: May, B, 2010-02-20 Polyubiquitination of PER proteins is directed by the Beta-TrCP1 component of SCF E3 ubiquitin ligase. The polyubiquitinated PER proteins are recognized and degraded by the 26S proteasome. Degradation of PER proteins occurs during the night and is necessary to allow new transcription of BMAL1:CLOCK/NPAS2 targets in the morning during the circadian cycle. Reactome Database ID Release 43400267 Reactome, http://www.reactome.org ReactomeREACT_25143 Reviewed: Albrecht, U, 2010-06-23 Reviewed: D'Eustachio, P, 2009-05-26 22:13:22 Reviewed: Delaunay, F, 2010-06-23 Reviewed: Hirota, T, 2010-06-23 Reviewed: Kay, SA, 2010-06-23