p-CRY1/2 FBXL3:CRY Binding of FBXL3 to Phosphorylated CRY proteins Authored: May, B, 2009-05-17 22:04:50 Edited: May, B, 2009-06-02 00:51:49 FBXL3 is an F-box type component of a particular SKP/CUL/F-Box E3 ubiquitin ligase. FBXL3 interacts specifically with CRY1 and CRY2 in the cytosol to direct the polyubiquitination of CRY1 and CRY2. It is unknown if FBXL3 requires phosphorylation or other modification of CRY proteins in order to bind and ubiquitinate them. Phosphorylation of CRY by Adenosine monophosphate-dependent kinase increases degradation of CRY, apparently by increasing association of CRY with FBXL3 Polyubiquitination of CRY proteins directs them to the 26S proteasome for degradation. Reactome Database ID Release 43400272 Reactome, http://www.reactome.org ReactomeREACT_25106 Reviewed: Albrecht, U, 2010-06-23 Reviewed: D'Eustachio, P, 2009-05-26 22:13:22 Reviewed: Delaunay, F, 2010-06-23 Reviewed: Hirota, T, 2010-06-23 Reviewed: Kay, SA, 2010-06-23