PathwayStep6610 PathwayStep6609 PathwayStep6608 PathwayStep6607 PathwayStep6606 PathwayStep6605 Egress of internalized antigen into cytosol from early endosome Exogenous soluble antigen targeted to more stable early endosome Movement of clathrin coated vesicles into early endosome Internalization of receptor bound antigen into clathrin coted vesicles Interaction of exogenous soluble antigen with its corresponding receptor Proteasomal clevage of exogenous antigen Cross-presentation of soluble exogenous antigens (endosomes) Authored: Garapati, P V, 2011-03-28 Edited: Garapati, P V, 2011-03-28 Exogenous soluble antigens are cross-presented by dendritic cells, albeit with lower efficiency than for particulate substrates. Soluble antigens destined for cross-presentation are taken up by distinct endocytosis mechanisms which route them into stable early endosomes and then to the cytoplasm for proteasomal degradation and peptide loading. GENE ONTOLOGYGO:0002479 Pubmed15592474 Pubmed17157489 Pubmed20171863 Reactome Database ID Release 431236978 Reactome, http://www.reactome.org ReactomeREACT_111056 Reviewed: Desjardins, M, English, L, 2011-05-13