PathwayStep6641 PathwayStep6642 PathwayStep6643 PathwayStep6644 PathwayStep6640 PathwayStep6639 PathwayStep6660 PathwayStep6656 PathwayStep6657 PathwayStep6658 PathwayStep6659 PathwayStep6651 PathwayStep6650 PathwayStep6655 PathwayStep6654 PathwayStep6653 PathwayStep6652 PathwayStep6647 PathwayStep6648 PathwayStep6645 PathwayStep6646 PathwayStep6649 PathwayStep769 Poliovirus precursor binds CD226 Nectin 2 binds CD226 Epithelial cadherin binds to KLRG1 CRTAM binds to NECL2 Ligands bind L-selectin NKG2A-CD94 heterdimer interacts with HLA-E Fc gamma receptors interact with antigen-bound IgG CD40 interacting with CD40L CD200 binds to CD200R MHC Class I interacts with CD160 KIR3DL2 interacting with HLA-A3 KIR2DL4 interacting with HLA-G KIR2DS1 interacting with HLA-C group 2 (Cw4) KIR2DS2 interacting with HLA-C group 1 (Cw3) C3d-complexed antigen binds to complement receptor KIR2DL1 interacting with HLA-C group 2 (Cw3) KIR3DL1 interacting with HLA Bw4 TCR complex interacts with peptide antigen-presenting MHC Class I KIR2DL2/3 interacting with HLA-C group 1 (Cw4) NKG2D homodimer interacting with ligands CD96 binds Nectin-like-5 LILRs interact with MHC Class I CXADR binds to AMICA1 MADCAM interacts with Integrin alpha4beta7 VCAM-1interacts with VLA-4 ICAMs 1-4 bind to Integrin LFA-1 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell A number of receptors and cell adhesion molecules play a key role in modifying the response of cells of lymphoid origin (such as B-, T- and NK cells) to self and tumor antigens, as well as to pathogenic organisms.<p><p>Molecules such as KIRs and LILRs form part of a crucial surveillance system that looks out for any derangement, usually caused by cancer or viral infection, in MHC Class I presentation. Somatic cells are also able to report internal functional impairment by displaying surface stress markers such as MICA. The presence of these molecules on somatic cells is picked up by C-lectin NK immune receptors.<p><p>Lymphoid cells are able to regulate their location and movement in accordance to their state of activation, and home in on tissues expressing the appropriate complementary ligands. For example, lymphoid cells may fine tune the presence and concentration of adhesion molecules belonging to the IgSF, Selectin and Integrin class that interact with a number of vascular markers of inflammation.<p><p>Furthermore, there are a number of avenues through which lymphoid cells may interact with antigen. This may be presented directly to a specific T-cell receptor in the context of an MHC molecule. Antigen-antibody complexes may anchor to the cell via a small number of lymphoid-specific Fc receptors that may, in turn, influence cell function further. Activated complement factor C3d binds to both antigen and to cell surface receptor CD21. In such cases, the far-reaching influence of CD19 on B-lymphocyte function is tempered by its interaction with CD21. Authored: de Bono, B, 2007-07-08 12:58:15 GENE ONTOLOGYGO:0050776 Pubmed11244041 Pubmed16603343 Pubmed16616474 Pubmed17218381 Reactome Database ID Release 43198933 Reactome, http://www.reactome.org ReactomeREACT_11152 Reviewed: Trowsdale, J, 2007-08-06 19:33:04 PathwayStep5906 PathwayStep5886 PathwayStep5885