PathwayStep6588 PathwayStep6589 PathwayStep6587 PathwayStep6590 PathwayStep6591 PathwayStep6592 Maturation of phagosome into phagolysosome Engulfment of particulate antigen into phagocytic vesicle Partial proteolysis of antigen in phagolysosomes Alkalization of the phagosomal lumen by NOX2 Escape of antigens from phagosome to cytosol Interaction of particulate antigens with dendritic cell receptors Cross-presentation of particulate exogenous antigens (phagosomes) Authored: Garapati, P V, 2011-03-28 Dendritic cells (DCs) take up and process exogenous particulate or cell-associated antigens such as microbes or tumor cells for MHC-I cross-presentation. Particulate antigens have been reported to be more efficiently cross-presented than soluble antigens by DCs (Khor et al. 2008). Particulate antigens are internalized by phagosomes. There are two established models that explain the mechanism by which exogenous particulate antigens are presented through MHC I; the cytosolic pathway where internalized antigens are somehow translocated from phagosomes into cytosol for proteasomal degradation and the vacuolar pathway (Lin et al. 2008, Amigorena et al. 2010). Edited: Garapati, P V, 2011-03-28 GENE ONTOLOGYGO:0002479 Pubmed18268517 Pubmed18572095 Pubmed20028659 Pubmed20171863 Reactome Database ID Release 431236973 Reactome, http://www.reactome.org ReactomeREACT_111174 Reviewed: Desjardins, M, English, L, 2011-05-13