Active Trk receptor complex:RIT/RIN-GTP Active Trk receptor complex:RIT/RIN-GTP:B-RAF B-RAF RIT/RIN-GTP binds B-RAF Authored: Nasi, S, Annibali, D, 2006-10-10 09:07:07 Edited: Jassal, B, 2006-10-10 09:20:18 Once activated by RIT or RIN, B-RAF activates, through MEK, the p38 MAP kinase. Whereas RIN appears to activate p38 (specifically the p38-alpha isoform) but not the ERKs, RIN was described to activate ERK1/ ERK2 as well, although to a much lower extent than p38. RIN signaling gives rise to sustained activation of p38 MAP kinase. Reactome Database ID Release 43187698 Reactome, http://www.reactome.org ReactomeREACT_12000 Reviewed: Greene, LA, 2007-11-08 15:39:37