Phospho-MAP kinase p38 (Mg2+ cofactor) MAP kinase p38 (Mg2+ cofactor) Binding and activation of MAP Kinase Authored: Nasi, S, Annibali, D, 2006-10-10 09:07:07 EC Number: 2.7.10 Edited: Jassal, B, 2006-10-10 09:20:18 Reactome Database ID Release 43171011 Reactome, http://www.reactome.org ReactomeREACT_12016 Reviewed: Greene, LA, 2007-11-08 15:39:37 The NGF activation of p38 MAP kinase is transient, being maximal at 10 min and declining to near control levels by 30 min. T180 and Y182 are two sites that become newly phosphorylated as p38 MAPK becomes activated. has a Stoichiometric coefficient of 2