Active MAPKAP kinase MAPKAP kinase MAP kinase activates MAPKAPK2, MAPKAPK3 and MSK1 Authored: Nasi, S, Annibali, D, 2006-10-10 09:07:07 EC Number: 2.7.11 Edited: Jassal, B, 2006-10-10 09:20:18 Pubmed8846784 Reactome Database ID Release 43187688 Reactome, http://www.reactome.org ReactomeREACT_12032 Reviewed: Greene, LA, 2007-11-08 15:39:37 has a Stoichiometric coefficient of 2 p38 MAPK is known to activate the Ser/Thr protein kinase MAPKAP kinase 2 and a closely related kinase, MAPKAP kinase 3, through phosphorylation at multiple sites. According to some authors, NGF does not induce any significant activation of MAPKAPK2 activity in PC12 cells. Potential p38 signaling effectors include transcription factors, such as cAMP-response element-binding protein and MEF2, cytoskeleton modulators, and a number of protein kinases. After activation, MAPKAP kinase 2 and 3 move to the nucleus.