PI3K alpha PI3K:p-KIT:sSCF dimer:p-KIT p-KIT complex Direct recruitment of PI3K to p-KIT Authored: Garapati, P V, 2011-07-11 Edited: Garapati, P V, 2011-07-11 Pubmed11520784 Pubmed15526160 Pubmed16129412 Pubmed16483568 Reactome Database ID Release 43205262 Reactome, http://www.reactome.org ReactomeREACT_111146 Reviewed: Rönnstrand, L, 2011-08-22 The regulatory subunit (p85) of PI3K interacts directly with phosphorylated Y721 of KIT via one of its SH2 domains. This binding leads to the activation of the catalytic domain (p110) of PI3K. SCF-induced PI3K recruitment mediates AKT activation through phospholipids at the membrane and to subsequent phosphorylation of the pro-apoptotic factor Bad as well as Fox3a.<br>PI3K activation mediates SCF-induced cell proliferation, survival, differentiation, adhesion, secretion and actin cytoskeletal organization.