VEGF-A,C,D,E bind to VEGFR2 leading to receptor dimerization Authored: Krupa, S, Gopinathrao, G, 2007-03-08 22:07:59 Edited: Gopinathrao, G, 2007-04-08 21:14:18 Pubmed11004490 Pubmed11387210 Pubmed12881528 Pubmed1417831 Pubmed15585754 Pubmed16336962 Pubmed16835467 Pubmed7824266 Pubmed8617204 Pubmed9207067 Pubmed9435229 Reactome Database ID Release 43194310 Reactome, http://www.reactome.org ReactomeREACT_12440 Reviewed: Claesson-Welsh, L, 2008-02-28 00:15:17 VEGFR-2 binds VEGF-A, -C, -D, and -E homodimers. VEGFR-2 is the primary mediator of the physiological effects of VEGF-A in angiogenesis, including microvascular permeability, endothelial cell proliferation, invasion, migration, and survival. In endothelial cells, these effects are mediated via activation of a phospholipase gamma-protein kinase C-Raf-MAPK signaling pathway for proliferation and PI3K and focal adhesion kinase for survival and migration. VEGFR-2 is the important receptor among VEGFR protiens and its activation and signaling may be positively or negatively regulated by co-expression and activation of various factors and other VEGF receptors like VEGFR-1 (Hicklin and Ellis 2005).The regulatory events of this receptor will be annotated in subsequent modules. has a Stoichiometric coefficient of 2 VEGFA,C,D,E