NRP-1 NRP-1 forms a ternary complex with VEGF165 and VEGFR1 Authored: Krupa, S, Gopinathrao, G, 2007-03-08 22:07:59 Edited: Gopinathrao, G, 2007-04-08 21:14:18 Plasma membrane-associated Neuropilin-1 (NRP1) binds vascular endothelial growth factor (VEGF) family members. NRP1 has three distinct extracellular domains, a1a2, b1b2, and c but lacks a distinct intracellular domain. VEGF165 mediates the formation of complexes containing VEGFR-2 and NRP-1, enhancing VEGF165-receptor binding on the endothelial cell membrane (Soker et al. 2002). The role of heparin, a critical component of NRP-1 interactions with VEGF proteins, will annotated in detail in future. Pubmed10842181 Pubmed11756651 Pubmed11948691 Pubmed11986311 Pubmed16763549 Reactome Database ID Release 43195408 Reactome, http://www.reactome.org ReactomeREACT_12494 Reviewed: Claesson-Welsh, L, 2008-02-28 00:15:17 has a Stoichiometric coefficient of 2 NRP1:VERGF165:VERGFR2