VEGF-C,D bind to VEGFR3 leading to receptor dimerization Authored: Krupa, S, Gopinathrao, G, 2007-03-08 22:07:59 Edited: Gopinathrao, G, 2007-04-08 21:14:18 Pubmed11532940 Pubmed12881528 Pubmed15585754 Pubmed8617204 Pubmed8700872 Pubmed9435229 Reactome Database ID Release 43194308 Reactome, http://www.reactome.org ReactomeREACT_12533 Reviewed: Claesson-Welsh, L, 2008-02-28 00:15:17 VEGFR-3 preferentially binds VEGF-C and -D. Mutations of the VEGFR-3 tyrosine kinase domain are seen in human lymphedema. VEGFR-3 expression has been correlated with transient lymphangiogenesis in wound healing and may modulate VEGFR-2 signaling in maintaining vascular integrity (Hicklin and Ellis 2005). has a Stoichiometric coefficient of 2 VEGF-C,D