Cleaved novel PDGF fragments Active PDGF dimers (CC, DD) Novel PDGF precursor dimers (CC, DD) Extracellular processing of novel PDGFs Authored: Garapati, P V, Jassal, B, 2008-11-24 10:14:27 During the extracellular proteolytic activation of PDGF-C and PDGF-D chains, the CUB domains is removed and plasmin protease has been shown to proteolytically cleave within the hinge regions, and thus releasing the corresponding growth factor domains. In addition the protease tissue-type plasminogen activator (tPA) is also involved in the activation of PDGF-CC but not able to cleave and activate PDGF-DD. EC Number: 3.4.21 Edited: Garapati, P V, Jassal, B, 2008-11-24 10:14:27 Pubmed15207811 Reactome Database ID Release 43382061 Reactome, http://www.reactome.org ReactomeREACT_16891 Reviewed: Heldin, CH, 2008-11-23 19:29:34 has a Stoichiometric coefficient of 2