Cleaved classical PDGF peptides Active PDGF dimers (AA, AB, BB) Classical PDGF precursor dimers (AA, AB, BB) Processing of classical PDGFs After dimerization of the PDGF-A and PDGF-B chains in the ER of producing cells, the dimers are proteolytically cleaved in the trans-Golgi network during protein maturation and secretion. The dibasic-specific proprotein convertase, furin, or related convertases are involved in the conversion of proPDGF forms to active PDGF forms. Authored: Garapati, P V, Jassal, B, 2008-11-24 10:14:27 EC Number: 3.4.21 Edited: Garapati, P V, Jassal, B, 2008-11-24 10:14:27 Pubmed15207811 Pubmed1639841 Reactome Database ID Release 43186785 Reactome, http://www.reactome.org ReactomeREACT_17059 Reviewed: Heldin, CH, 2008-11-23 19:29:34