Activated TrkA receptor complex:Clathrin-coated vesicle Activated TrkA receptor complex:Clathrin-coated vesicle Endocytosis (internalization) of clathrin-coated vesicle Authored: Nasi, S, Annibali, D, 2006-10-10 09:07:07 Dynamin is a microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. It is involved in vesicle trafficking processes and is necessary for endocytosis. Dynamins are large GTPases that bind to PIP2-containing membranes, several SH3-domain containing proteins and cytoskeletal modifiers. They self-polymerize in a GTP dependent manner, catalyzing the scission of invaginating membranes during endocytosis (Praefcke & McMahon, 2004). There are three dynamins in humans: dynamin I is neuron-specific; dynamin II shows ubiquitous expression; dynamin III is expressed in testis, brain, lung and blood platelets. EC Number: 3.6.5.1 EC Number: 3.6.5.2 EC Number: 3.6.5.3 EC Number: 3.6.5.4 Edited: Jassal, B, 2006-10-10 09:20:18 Pubmed15040446 Reactome Database ID Release 43177501 Reactome, http://www.reactome.org ReactomeREACT_12397 Reviewed: Greene, LA, 2007-11-08 15:39:37