Activated TrkA receptor complex Active TrkA receptor:PLCG1 complex Binding of PLCG1 to active TrkA receptor Authored: Nasi, S, Annibali, D, 2006-10-10 09:07:07 Edited: Jassal, B, 2006-10-10 09:20:18 Reactome Database ID Release 43167674 Reactome, http://www.reactome.org ReactomeREACT_11998 Reviewed: Greene, LA, 2007-11-08 15:39:37 The PLC-gamma 1 docking site in Trk receptor (Y785) is important for initiation and maintenance of hippocampal LTP (long term potentiation); this residue in TrkA receptor also binds to CHK tyrosine kinase, which participates in MAPK pathway activation and is involved in PC12 cells neurite outgrowth in response to NGF. PLC-gamma 1 activation results in long term induction of a sodium channel gene (PN1).