Crk isoforms Crk binds to the active PDGF receptor Authored: Garapati, P V, Jassal, B, 2008-11-24 10:14:27 Crk family of adaptor molecules consists of CrkI with one SH2 and one SH3 domains and CrkII and CrkL with one SH2 and two SH3 domains each. They bind to Tyr762 of the PDGF alpha-receptor and represent the only known SH2-domain containing molecule which binds with significantly higher affinity to the alpha-receptor than to the beta-receptor. Edited: Garapati, P V, Jassal, B, 2008-11-24 10:14:27 Pubmed10508235 Pubmed9546424 Pubmed9739761 Reactome Database ID Release 43382056 Reactome, http://www.reactome.org ReactomeREACT_16940 Reviewed: Heldin, CH, 2008-11-23 19:29:34 PDGF:Phospho-PDGF receptor dimer:Crk PDGF:Phospho-PDGF receptor dimer