GRB2:SOS1 Grb2/Sos1 complex binds to the active receptor Authored: Garapati, P V, Jassal, B, 2008-11-24 10:14:27 Edited: Garapati, P V, Jassal, B, 2008-11-24 10:14:27 Grb2 is an adaptor molecule containing one SH2 domain and two SH3 domains. The SH2 domain of Grb2 binds directly to autophosphorylated PDGF receptors and with its SH3 domain it forms a complex with Sos1. The binding of Grb2/Sos1 to the PDGF receptor juxtaposes the complex towards Ras molecules leading to Ras activation. Ras is implicated in the MAP kinase cascade, a pathway in cell growth stimulation, migration and differentiation.<br> Pubmed7935391 Pubmed8388543 Pubmed9739761 Reactome Database ID Release 43186826 Reactome, http://www.reactome.org ReactomeREACT_16901 Reviewed: Heldin, CH, 2008-11-23 19:29:34 PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 PDGF:Phospho-PDGF receptor dimer