Activation of Src Activation of Src kinases involves displacement of Tyr527 from the SH2 domain and phosphorylation of other tyrosine residues in the kinase domain. Src activation appears to be important for the mitogenic response of PDGF. Authored: Garapati, P V, Jassal, B, 2008-11-24 10:14:27 EC Number: 2.7.10 Edited: Garapati, P V, Jassal, B, 2008-11-24 10:14:27 Pubmed8647855 Pubmed9739761 Reactome Database ID Release 43380780 Reactome, http://www.reactome.org ReactomeREACT_16991 Reviewed: Heldin, CH, 2008-11-23 19:29:34 PDGF:Phospho-PDGF receptor dimer:Src PDGF:Phospho-PDGF receptor dimer:phospho-Src