PI3K catalyses the phosphorylation of PIP2 to PIP3 Authored: Garapati, P V, Jassal, B, 2008-11-24 10:14:27 EC Number: 2.7.1.153 Edited: Garapati, P V, Jassal, B, 2008-11-24 10:14:27 PI3K's preferred substrate is phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] which is phosphorylated to the trisphosphate [PI(3,4,5)P3]. PI3-kinase and its products have been found to be of importance in PDGF-stimulated actin reorganization, and directed cell movement, as well as in the stimulation of cell growth and inhibition of apoptosis. Pubmed2466336 Pubmed9739761 Reactome Database ID Release 43186800 Reactome, http://www.reactome.org ReactomeREACT_16877 Reviewed: Heldin, CH, 2008-11-23 19:29:34