IkB(alpha):NF-kB complex NF-kB complex IKKbeta phosphorylates IkB causing NF-kB to dissociate Authored: Nasi, S, Annibali, D, 2006-10-10 09:07:07 EC Number: 2.7.11 Edited: Jassal, B, 2008-05-20 12:26:36 IkB is an inhibitory protein that sequesters NF-kB in the cytoplasm, by masking a nuclear localization signal, located just at the C-terminal end in each of the NF-kB subunits. A key event in NF-kB activation involves phosphorylation of IkB by an IkB kinase (IKK). NGF stimulates the activity of the IkB kinase IKK-beta, and, possibly, IKK-alpha as well. Once IkB is phosphorylated, the IkB:NF-kB complex dissociates. Pubmed9252186 Reactome Database ID Release 43193705 Reactome, http://www.reactome.org ReactomeREACT_13502 Reviewed: Chao, MV, 2008-05-28 09:46:01 Reviewed: Friedman, WJ, 2008-05-20 12:23:46 has a Stoichiometric coefficient of 2