ubiquitin NGF ligand:p75NTR:Phospho-IRAK1:polyubiquitinated TRAF6:p62 NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 TRAF6 is auto-ubiquitinated Authored: Nasi, S, Annibali, D, 2006-10-10 09:07:07 Edited: Jassal, B, 2008-05-20 12:26:36 Pubmed15465037 Reactome Database ID Release 43209566 Reactome, http://www.reactome.org ReactomeREACT_13753 Reviewed: Chao, MV, 2008-05-28 09:46:01 Reviewed: Friedman, WJ, 2008-05-20 12:23:46 The activity of TRAF6 is regulated by autoubiquitination. This process, in turn, is regulated by p62. Cells devoid of p62 exhibit low basal TRAF6 polyubiquitination. When p62 is expressed, auto-ubiquitination of TRAF6 is enhanced. The details curated in this event represent the ubiquitination of TRAF6, even as ubiquitin is shown as 1 stoichiometrically.