Ubiquitinated NRIF:Sequestosome Ubiquitinated NRIF:Sequestosome Polyubiquitinated NRIF migrates to the nucleus Authored: Nasi, S, Annibali, D, 2006-10-10 09:07:07 Edited: Jassal, B, 2008-05-20 12:26:36 NRIF polyubiquitination is necessary for nuclear translocation. The carboxyl terminus of NRIF mediates nuclear localization, whereas the amino terminus prevents it. Once in the nucleus, NRIF regulates gene expression, acting as a transcriptional repressor. Pubmed16630834 Reactome Database ID Release 43204947 Reactome, http://www.reactome.org ReactomeREACT_13601 Reviewed: Chao, MV, 2008-05-28 09:46:01 Reviewed: Friedman, WJ, 2008-05-20 12:23:46