NGF ligand:p75NTR:NADE:14-3-3epsilon YWHAE dimer NGF:p75NTR:NADE 14-3-3epsilon attentuates NADE-related apoptosis Authored: Nasi, S, Annibali, D, 2006-10-10 09:07:07 Edited: Jassal, B, 2008-05-20 12:26:36 NADE forms a complex with the 14-3-3epsilon isoform. The last one interacts with caspase 3 through its C terminal region. The NADE:4-3-3epsilon complex negatively regulates p75NTR-mediated apoptosis, probably by down regulating caspase activity. Pubmed11278287 Reactome Database ID Release 43204981 Reactome, http://www.reactome.org ReactomeREACT_13657 Reviewed: Chao, MV, 2008-05-28 09:46:01 Reviewed: Friedman, WJ, 2008-05-20 12:23:46