Procaspase2/3 active Caspase2/3 p75NTR:NADE promotes caspase2/3 activation Authored: Nasi, S, Annibali, D, 2006-10-10 09:07:07 Edited: Jassal, B, 2008-05-20 12:26:36 Once bound to the NGF:p75NTR complex, NADE contributes to cell death signalling by promoting activation of caspases 2 and 3. It is unclear whether JNK activation is involved. The apoptotic function of NADE was observed in oligodendrocytes (Mukai et al. 2002). Pubmed11830582 Reactome Database ID Release 43205117 Reactome, http://www.reactome.org ReactomeREACT_13533 Reviewed: Chao, MV, 2008-05-28 09:46:01 Reviewed: Friedman, WJ, 2008-05-20 12:23:46