NRIF NGF ligand:p75NTR:NRIF:TRAF6 TRAF6 homotrimer mature NGF homodimer:p75NTR gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 Authored: Nasi, S, Annibali, D, 2006-10-10 09:07:07 EC Number: 3.4 Edited: Jassal, B, 2008-05-20 12:26:36 Neurotrophin or proneurotrophin signalling promotes p75NTR cleavage by gamma-secretase, allowing the release of p75 ICD and NRIF. This mechanism was shown in sympathetic neurons.<br>Gamma-secretase can be activated in a number of ways, including signalling via p75NTR. The phorbol esther PMA induces p75 cleavage, followed by NRIF nuclear translocation, after 30 min. Neurotrophin binding to p75, instead, triggers the same events only after 12 h. Pubmed16630834 Reactome Database ID Release 43205112 Reactome, http://www.reactome.org ReactomeREACT_13710 Reviewed: Chao, MV, 2008-05-28 09:46:01 Reviewed: Friedman, WJ, 2008-05-20 12:23:46