NGF ligand:p75NTR:NRIF NGF ligand:p75NTR:NRIF:TRAF6 TRAF6 homotrimer TRAF6 binds to p75NTR:NRIF Authored: Nasi, S, Annibali, D, 2006-10-10 09:07:07 Edited: Jassal, B, 2008-05-20 12:26:36 Pubmed14960584 Reactome Database ID Release 43193669 Reactome, http://www.reactome.org ReactomeREACT_13785 Reviewed: Chao, MV, 2008-05-28 09:46:01 Reviewed: Friedman, WJ, 2008-05-20 12:23:46 Upon neurotrophin stimulation, p75NTR interacts with the ubiquitin 3 ligase TRAF6 (TNF receptor-associated factor 6). It is unclear whether TRAF6 binds to p75NTR directly, or whether it needs to be recruited through an adaptor protein such as MyD88.Recruitment of NRIF and TRAF6 to p75NTR is followed by an interaction between the two cytoplasmic proteins, It is possible that the NRIF:TRAF6 interaction promotes formation of a multimeric signalling complex. TRAF6 appears to promote NRIF release from p75NTR