insulin receptor phospho-insulin receptor Insulin receptor de-phosphorylation Authored: Bevan, AP, 2003-07-31 08:01:55 EC Number: 3.1.3.48 Pubmed18406720 Pubmed9609117 Reactome Database ID Release 4374733 Reactome, http://www.reactome.org ReactomeREACT_453 With insulin dissociated from its receptor the signal to sustain the receptor kinase's activity is also removed. Thus endosomally-associated protein tyrosine phosphatases (PTPs) are able to dephosphorylate the receptor which now can not rephosphorylate themselves since insulin is removed and the receptor is in the inactive protein conformation. (The identity of these PTPs is not clearly established yet. A discussion of candidates will be added in the near future.)<p>The dephosphorylation of the receptor is also a signal for the receptor to recycle back to the plasma membrane. has a Stoichiometric coefficient of 12