Rheb:GDP Rheb:GTP TSC2 activates intrinsic GTPase activity of Rheb Authored: Katajisto, P, Makela, T, Wu, J, 2008--1-1- Edited: Jassal, B, 2008-11-19 15:14:38 Pubmed12869586 Pubmed12906785 Reactome Database ID Release 43380979 Reactome, http://www.reactome.org ReactomeREACT_21261 Reviewed: Zheng, B, 2009-10-20 TSC2 (in the TSC complex) functions as a GTPase-activating protein and stimulates the intrinsic GTPase activity of a small G-protein Rheb. This results in the conversion of Rheb-GTP into Rheb-GDP and in the inhibition of the mTOR activation by GTP-bound Rheb (Inoki K et al, 2003; Tee AR et al, 2003).