GRB2:SOS1 p-IRS1,2 GRB2:SOS:IRS-P GRB2:SOS binds IRS-P Authored: Charalambous, M, 2005-01-07 11:17:43 Edited: Schmidt, EE, 0000-00-00 00:00:00 Inactive p21ras-GDP is found anchored to the plasma membrane by a farnesyl residue.<br>Insulin stimulation results in phosphorylation of IRS1/2 on tyrosine residues (Y). GRB2 binds the phosphotyrosine residues of IRS via its SH2 domain. As IRS is phosphorylated by the insulin receptor near to the plasma membrane, the SOS-GRB2:IRS interaction brings the SOS enzyme into close proximity to p21ras. Pubmed8316835 Pubmed8530377 Pubmed8621421 Pubmed8810325 Pubmed9003010 Pubmed9832424 Pubmed9852124 Reactome Database ID Release 4374736 Reactome, http://www.reactome.org ReactomeREACT_646