GRB2:SOS1 p-SHC GRB2:SOS:Phospho-SHC GRB2:SOS binds to SHC-P Authored: Charalambous, M, 2005-01-07 11:17:43 Edited: Schmidt, EE, 0000-00-00 00:00:00 Pubmed8810325 Reactome Database ID Release 4374746 Reactome, http://www.reactome.org ReactomeREACT_176 Reviewed: Greene, LA, 2007-11-08 15:39:37 Tyrosine receptor kinase stimulation phosphorylates Shc which recruits the SH2 domain of the adaptor protein GRB2, which is complexed with SOS, an exchange factor for p21ras and RAC, through its SH3 domain. Besides SOS, the GRB2 SH3 domain can associate with other intracellular targets, including GAB1. Erk and Rsk mediated phosphorylation results in dissociation of the SOS-GRB2 complex. This may explain why Erk activation through Shc and SOS-GRB2 is transient. Inactive p21ras-GDP is found anchored to the plasma membrane by a farnesyl residue. As Shc is phosphorylated by the the stimulated receptor near to the plasma membrane, the SOS-GRB2:Shc interaction brings the SOS enzyme into close proximity to p21ras.