Myelin component p75NTR:NgR:LINGO1 p75NTR:NgR:LINGO1:myelin component Myelin components can interact with p75NTR:NgR:LINGO1 A group of myelin components named MDGIs (myelin-derived growth-inhibitors), bind to NgR and inhibit neurite outgrowth. Examples of such components are NOGO, OMGP (oligodendrocyte myelin glycoprotein) and MAG (myelin-associated glycoprotein). The amino-terminal region of NgR, covering eight leucine-rich repeats (LRR) and the LRR carboxy-terminal domain (LRRCT) is sufficient to interact with MAG, OMGP and NOGO. Their binding to NgR enhances the NgR-p75 interaction.These inhibitors bind to a receptor complex made up of the NOGO receptor, NgR, and p75NTR. Such complexes then activate RHOA, thereby inhibiting axonal growth. Authored: Nasi, S, Annibali, D, 2006-10-10 09:07:07 Edited: Jassal, B, 2008-05-20 12:26:36 Pubmed12426574 Reactome Database ID Release 43193655 Reactome, http://www.reactome.org ReactomeREACT_13496 Reviewed: Chao, MV, 2008-05-28 09:46:01 Reviewed: Friedman, WJ, 2008-05-20 12:23:46