RhoA (Mg cofactor):GDP RHOA:RHO-GDI:p75NTR:NgR:myelin component RHO-GDI:p75NTR:NgR:myelin component The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA Authored: Nasi, S, Annibali, D, 2006-10-10 09:07:07 Edited: Jassal, B, 2008-05-20 12:26:36 Pubmed12692556 Reactome Database ID Release 43193696 Reactome, http://www.reactome.org ReactomeREACT_13732 Reviewed: Chao, MV, 2008-05-28 09:46:01 Reviewed: Friedman, WJ, 2008-05-20 12:23:46 The p75NTR:RHO-GDI complex appears to be strengthened in presence of a GMDI (MAG, NOGO or OMGP) bound to a NgR:p75 complex. When in a complex with MDGIs and NgR, p75NTR restrains the activity of RHO-GDI (GDP Dissociation Inhibitor). This facilitates the displacement of RHO-GDI from RHOA.