SARA TGFB1:TGFBR2:TGFBR1 GADD34:PP1 TGFB1:p-TGFBR:I-SMAD7:GADD34:PP1:SARA PP1 dephosphorylates TGFBR1 Authored: Heldin, CH, Moustakas, A, Huminiecki, L, Jassal, B, 2006-02-02 EC Number: 3.1.3.16 Edited: Jassal, B, 2012-04-10 PP1 dephosphorylates TGF-beta receptor-1 (TGFBR1), thereby inhibiting TGF-beta signaling. It has not been precisely examined whether PP1 dephosphorylates all TGFBR1 serine and threonine residues phosphorylated by TGFBR2 (Shi et al. 2004). This was inferred from experiments that used a recombinant mouse Smad7 and recombinant human TGFBR1, TGFBR2 and PP1. Pubmed14718519 Reactome Database ID Release 43178178 Reactome, http://www.reactome.org ReactomeREACT_121355 Reviewed: Huang, Tao, 2012-05-14 has a Stoichiometric coefficient of 6