TGFB1:TGFBR2:TGFBR1 TGFB1:TGFBR2:p-TGFBR1 TGFBR2 phosphorylates TGFBR1 Authored: Heldin, CH, Moustakas, A, Huminiecki, L, Jassal, B, 2006-02-02 Edited: Jassal, B, 2006-01-18 10:19:52 Formation of the hetero-tetrameric TGF-beta-1 receptor complex induces receptor rotation, so that TGFBR2 and TGFBR1 cytoplasmic kinase domains face each other in a catalytically favourable configuration. The constitutively active type II receptor kinase (which auto-phosphorylates in the absence of ligand), trans-phosphorylates specific serine residues at the conserved Gly-Ser-rich juxtapositioned domain (GS domain) of the type I receptor (Wrana et al. 1994, Souchelnytskyi et al. 1996).<br><br>In addition to phosphorylation, TGFBR1 may also be sumoylated in response to TGF-beta-1 stimulation. Sumoylation enhances TGFBR1 function by facilitating recruitment and phosphorylation of SMAD3 (Kang et al. 2008). Pubmed8047140 Pubmed8947046 Reactome Database ID Release 43170843 Reactome, http://www.reactome.org ReactomeREACT_6816 Reviewed: Heldin, CH, 2006-04-18 14:26:12 Reviewed: Huang, Tao, 2012-05-14 Type II receptor phosphorylates type I receptor has a Stoichiometric coefficient of 12