TGFB1:TGFBR2:TGFBR1 Dimeric TGFB1:TGFBR2 homodimer TGFBR1:FKBP1A TGFBR2 recruits TGFBR1 Authored: Heldin, CH, Moustakas, A, Huminiecki, L, Jassal, B, 2006-02-02 Edited: Jassal, B, 2006-01-18 10:19:52 Edited: Jassal, B, 2012-04-10 Pubmed1333888 Pubmed7693660 Pubmed8242743 Pubmed9233797 Reactome Database ID Release 43170846 Reactome, http://www.reactome.org ReactomeREACT_6945 Reviewed: Heldin, CH, 2006-04-18 14:26:12 Reviewed: Huang, Tao, 2012-05-14 The protein complex of dimeric TGF-beta-1 with the type II receptor dimer (Dimeric TGFB1:TGFBR2 homodimer) recruits the low affinity receptor, type I receptor (TGFBR1), which is also known to pre-exist in a dimeric form, thus forming a hetero-tetrameric receptor bound to the dimeric ligand on the extracellular face of the plasma membrane (TGFB1:TGFBR2:TGFBR1). FKBP1A (FKBP12), a peptidyl-prolyl cis-trans isomerase, forms a complex with TGFBR1 and prevents phosphorylation of TGFBR1 by TGFBR2 in the absence of ligand. FKBP1A dissociates from TGFBR1 after it forms a complex with ligand-activated TGFBR2. Type II receptor recruits type I receptor has a Stoichiometric coefficient of 2