UCHL5/USP15 TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7 TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7:UCHL5/USP15 UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1 Authored: Orlic-Milacic, M, 2012-04-04 Edited: Jassal, B, 2012-04-10 Pubmed16027725 Pubmed22344298 Reactome Database ID Release 432179293 Reactome, http://www.reactome.org ReactomeREACT_120979 Reviewed: Huang, Tao, 2012-05-14 Ubiquitin C-terminal hydrolase UCHL5 (UCH37) strongly binds to SMAD7 and is thereby recruited to TGF-beta receptor complex (Wicks et al. 2005). Another ubiquitin peptidase, USP15, has recently been found to associate with ubiquitinated TGFBR1 through SMAD7 (Eichhorn et al. 2012). The role of UCHL5 was inferred from experiments using recombinant mouse Uchl5 and Smad7 with recombinant human TGF-beta receptors. The role of USP15 was established by experiments with human proteins.