TGFB1:TGFBR2:p-TGFBR1 TGFB1:TGFBR2:p-TGFBR1:SMAD7:SMURF/NEDD4L SMAD7:SMURF/NEDD4L SMAD7:SMURF complex binds to phosphorylated TGFBR1 Authored: Heldin, CH, Moustakas, A, Huminiecki, L, Jassal, B, 2006-02-02 Edited: Jassal, B, 2012-04-10 Pubmed11163210 Pubmed11278251 Pubmed15496141 Reactome Database ID Release 43178218 Reactome, http://www.reactome.org ReactomeREACT_121080 Reviewed: Huang, Tao, 2012-05-14 SMAD7 binds to phosphorylated TGFBR1 (TGF-beta receptor I), thereby recruiting SMURF1 (Ebisawa et al. 2001), SMURF2 (Kavsak et al. 2000) or NEDD4L (Kuratomi et al. 2005) ubiquitin ligases to the activated TGF-beta receptor complex. This is based on experiments in which recombinant mouse Smad7 was used together with recombinant human ubiquitin ligases and TGF-beta receptors.