CYP3A5 oxidises aflatoxin B1 to aflatoxin-8,9-oxide Aflatoxins are produced by the fungal molds Aspergillus flavus and Aspergillus parasiticus. Dietary contamination accounts for adverse health problems including liver cancer therby classifying aflatoxins as a Group 1 carcinogen in humans.Aflatoxin B1 (AFB1) is especially carcinogenic in a number of species including humans.<br>AFB1 requires microsomal oxidation to produce epoxides which are the cause of their toxic and carcinogenic effects. In humans, both CYP3A4 and CYP3A5 are able to produce epoxide stereoisomers of AFB1, the most potent being aflatoxin exo-8,9-oxide (AFBO). Authored: Jassal, B, 2008-05-19 12:57:01 Edited: Jassal, B, 2008-05-19 12:57:01 Pubmed15454734 Reactome Database ID Release 43213175 Reactome, http://www.reactome.org ReactomeREACT_13734 Reviewed: D'Eustachio, P, 2008-05-28 08:30:54