Benzene is hydroxylated to phenol
Authored: Jassal, B, 2008-05-19 12:57:01
Benzene + O<sub>2</sub> + NADPH + H<sup>+</sup> -> Phenol + H<sub>2</sub>O + NADP<sup>+</sup>
Benzene is an occupational and environmental toxicant and is implicated in myelogenous leukemia. For toxicity to occur, benzene is oxidised to phenol and subsequently to catechol and hydroquinone. CYP2E1 is the enzyme responsible for oxidation of benzene to phenol.
Edited: Jassal, B, 2008-05-19 12:57:01
GENE ONTOLOGYGO:0018910
Pubmed11701230
Reactome Database ID Release 4376416
Reactome, http://www.reactome.org
ReactomeREACT_228
Reviewed: D'Eustachio, P, 2008-05-28 08:30:54