Glc,Fuc-Pre-NOTCH Glc,Fuc-Pre-NOTCH Transport of NOTCH precursor to Golgi Authored: Jassal, B, 2004-12-15 13:08:03 Edited: D'Eustachio, P, 2012-02-06 Edited: Orlic-Milacic, M, 2012-02-10 NOTCH receptor precursors (Pre-NOTCH) traffic from the endoplasmic reticulum to the Golgi. Endoplasmic reticulum calcium ATPases are required for maintenance of high levels of calcium and positively regulate NOTCH trafficking, perhaps by ensuring proper NOTCH folding. Exit of NOTCH precursors from the endoplasmic reticulum is negatively regulated by SEL1L (Li et al. 2010, Sundaram et al. 1993), an endoplasmic reticulum membrane protein that is part of the ERAD (endoplasmic reticulum associated degradation) system, which performs quality control and triggers degradation of misfolded proteins (Francisco et al. 2010). NOTCH trafficking through the Golgi and trans-Golgi network is positively regulated by RAB6, a Golgi membrane GTPase. Pubmed10459009 Pubmed10545110 Pubmed1295745 Pubmed1764995 Pubmed20170518 Pubmed20197277 Pubmed7918097 Pubmed8293978 Pubmed8681805 Pubmed9244302 Reactome Database ID Release 431912374 Reactome, http://www.reactome.org ReactomeREACT_118577 Reviewed: Haw, R, 2012-02-06 Reviewed: Joutel, A, 2004-12-15