N-atom dealkylation of caffeine Authored: Jassal, B, 2008-05-19 12:57:01 Caffeine is one of the world's most frequently consumed xenobiotic. The major source of caffeine comes from tea and coffee. Caffeine is extensively metabolized in humans with at least 17 metabolites formed in its biotransformation. CYP1A2 is a prominent enzyme in the formation of an important metabolite of caffeine (paraxanthine) by N3-demethylation. Edited: Jassal, B, 2008-05-19 12:57:01 Pubmed8553685 Reactome Database ID Release 4376426 Reactome, http://www.reactome.org ReactomeREACT_1165 Reviewed: D'Eustachio, P, 2008-05-28 08:30:54